We reviewed the conservation status of rare and endangered species of mussels in southeastern Oklahoma by completing surveys of 10 long-term monitoring sites on the Kiamichi River and five sites in the Little River. We found extant populations of the Ouachita rock pocketbook, Arkansia wheeleri, scaleshell, Leptodea leptodon, winged mapleleaf, Quadrula fragosa, and rabbitsfoot, Quadrula cylindrica cylindrica. This is the first reported documentation of Q. fragosa in the Little River. When our data are compared to historic records, populations, particularly of A. wheeleri and Q. cylindrica, appear to be declining.